PUBLICATIONS

2025

Borisov N, Ilnytsky Y, Byeon B, Kovalchuk O, Kovalchuk I. Multi-omics data integration for topology-based pathway activation assessment and personalized drug ranking. Molecular Omics, 2025
Vardazaryan N, Adunts L, Bazukyan I, Zakharyan M, Liu H, Melkonian Ch, Nersisyan L. Global distribution of honeybee gut microbiome and pesticide-driven adaptations in opportunistic microbial species. BioRxiv, 2025.
Binder H, Hampel U, Loeffler-Wirth H, Hansmann F, Pfannkuche H, Schmidt M, Schneider MR. Spatial transcriptome analysis of the human eyelid depicts meibomian gland cell differentiation: A pilot study. Physiological Reports, 2025
Schmidt M, Binder H, Schneider MR. The metabolic underpinnings of sebaceous lipogenesis. Communications Biology, 2025
Konecny T, Asatryan A, Binder H. Responding to Stress: Diversity and Resilience of Grapevine in a Changing Climate Under the Perspective of Omics Research. International Journal of Molecular Sciences, 2025
Hakobyan S, Schmidt M, Binder H, Arakelyan A. Topology-aware pathway analysis of spatial transcriptomics. PeerJ, 2025
Hakobyan M, Binder H, Arakelyan A. Telomere Maintenance Pathways in Lower-Grade Gliomas: Insights from Genetic Subtypes and Telomere Length Dynamics. International Journal of Molecular Sciences, 2025
Jalatyan T, Aznauryan E, Hasan R, Vardanyan V, Nersisyan S, Thompson DB, Davidsohn N, Thomas S, van Haren S, Tam J, Milanova D, Church GM, Nersisyan L. hafoe: an interactive tool for the analysis of chimeric AAV libraries after random mutagenesis. Gene Therapy, 2025
Zhang Y, Nersisyan L, Fürst E, Alexopoulos I, Santolaria C, Huch S, Bassot C, Garre E, Sunnerhagen P, Piazza I, Pelechano V. Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay. Molecular Cell, 2025
Arakelyan A, Sirunyan T, Khachatryan G, Hakobyan S, Minasyan A, Nikoghosyan M, Hakobyan M, Chavushyan A, Martirosyan G, Hakobyan Y, Binder H. Assigning Transcriptomic Subtypes to Chronic Lymphocytic Leukemia Samples Using Nanopore RNA-Sequencing and Self-Organizing Maps. Cancers (Basel), 2025

2024

Ghukasyan L, Khachatryan G, Sirunyan T, Minasyan A, Hakobyan S, Chavushyan A, Hayrapetyan V, Ghazaryan H, Martirosyan G, Mkrtchyan G, Vardanyan V, Mukuchyan V, Davidyants A, Zakharyan R, Arakelyan A. Genewise detection of variants in MEFV gene using nanopore sequencing. Frontiers in Genetics, 2024
Wahis J, Akkaya C, Kirunda AM, Mak A, Zeise K, Verhaert J, Gasparyan H, Hovhannisyan S, Holt MG. The astrocyte α1A-adrenoreceptor is a key component of the neuromodulatory system in mouse visual cortex. Glia, 2024
Martirosyan A, Ansari R, Pestana F, Hebestreit K, Gasparyan H, Aleksanyan R, Hnatova S, Poovathingal S, Marneffe C, Thal DR, Kottick A, Hanson-Smith VJ, Guelfi S, Plumbly W, Belgard TG, Metzakopian E, Holt MG. Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolutionMolecular Neurodegeneration, 2024
Bielefeld P, Martirosyan A, Martín-Suárez S, Apresyan A, Meerhoff GF, Pestana F, Poovathingal S, Reijner N, Koning W, Clement RA, Van der Veen I, Toledo EM, Polzer O, Durá I, Hovhannisyan S, Nilges BS, Bogdoll A, Kashikar ND, Lucassen PJ, Belgard TG, Encinas JM, Holt MG, Fitzsimons CP. Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice. Nature Communications, 2024
Turnbull K, Paternoga H, von der Weth E, Egorov AA, Pochopien AA, Zhang Y, et al. The ABCF ATPase New1 resolves translation termination defects associated with specific tRNAArg and tRNALys isoacceptors in the P site. Nucleic Acids Research, 2024
Davitavyan S, Martirosyan G, Mkrtchyan G, Chavushyan A, Melkonyan A, Ghazaryan H, Binder H, Arakelyan A: Integrated analysis of -omic landscapes in breast cancer subtypes. F1000Research, 2024
Hakobyan A, Meyenberg M, Vardazaryan N, Hancock J, Vulliard L, Loizou JI, et al. Pan-cancer analysis of the interplay between mutational signatures and cellular signaling. iScience, 2024
Hakobyan M, Binder H, Arakelyan A. Pan-canceranalysis of telomere maintenance mechanisms. Journal of Biological Chemistry, 2024
Schmidt M․, Avagyan S․, Reiche K., Binder B., Loeffler-Wirth H. (2024). A Spatial Transcriptomics Browser for Discovering Gene Expression Landscapes across Microscopic Tissue Sections. Current Issues in Molecular Biology, 2024
Arakelyan A, Avagyan S, Kurnosov A, Mkrtchyan T, Mkrtchyan G, Zakharyan R, R Mayilyan K, Binder H. Temporal changes of gene expression in health, schizophrenia, bipolar disorder, and major depressive disorder. Schizophrenia, 2024

2023

Staroverov V, Nersisyan S, Galatenko A, Alekseev D, Lukashevich S, Polyakov F, Anisimov N, Tonevitsky A. Development of a novel mathematical model that explains SARS-CoV-2 infection dynamics in Caco-2 cells. PeerJ, 2023
Dong Y, Duan S, Xia Q, Liang Z, Dong X, Margaryan K, Musayev M, Goryslavets S, Zdunić G, Bert PF, Lacombe T, Maul E, Nick P, Bitskinashvili K, Bisztray GD, Drori E, De Lorenzis G, Cunha J, Popescu CF, Arroyo-Garcia R, Arnold C, Ergül A, Zhu Y, Ma C, Wang S, Liu S, Tang L, Wang C, Li D, Pan Y, Li J, Yang L, Li X, Xiang G, Yang Z, Chen B, Dai Z, Wang Y, Arakelyan A, et al. Dual domestications and origin of traits in grapevine evolution. Science, 2023
Everest-Dass A, Nersisyan S, Maar H, Novosad V, Schröder-Schwarz J, Freytag V, et al. Spontaneous metastasis xenograft models link CD44 isoform 4 to angiogenesis, hypoxia, EMT and mitochondria-related pathways in colorectal cancer. Molecular Oncology, 2024
Hakobyan S, Stepanyan A, Nersisyan L, Binder H, Arakelyan A. PSF toolkit: an R package for pathway curation and topology-aware analysis. Frontiers in Genetics, 2023
Avagyan S, Binder H. Subtyping or not subtyping—Quo vadis for precision medicine of colorectal cancer. Translational Cancer Research, 2023
Huch S, Nersisyan L, Ropat M, Barrett D, Wu M, Wang J, et al. Atlas of mRNA translation and decay for bacteria. Nature Microbiology, 2023
Zhiyanov A, Engibaryan N, Nersisyan S, Shkurnikov M, Tonevitsky A. Differential co-expression network analysis with DCoNA reveals isomiR targeting aberrations in prostate cancer. Bioinformatics, 2023
Magaryan K, Nikogհosyan M, Baloyan A, Gasoyan H, Hovhannisyan E, Galstyan L, ... Binder H, Machine learned-based visualization of the diversity of grapevine genomes worldwide and in Armenia using SOMmelier. BIO Web Conferences, 2023
Shkurnikov M, Nersisyan S, Averinskaya D, Chekova M, Polyakov F, Titov A, et al. HLA-A*01:01 allele diminishing in COVID-19 patients population associated with non-structural epitope abundance in CD8+ T-cell repertoire. PeerJ, 2023

2022

Avetyan D, Hakobyan S, Nikoghosyan M, Ghukasyan L, Khachatryan G, Sirunyan T, Muradyan N, Zakharyan R, Chavushyan A, Hayrapetyan V, Hovhannisyan A, Mohamed Bakhash SA, Jerome KR, Roychoudhury P, Greninger AL, Niazyan L, Davidyants M, Melik-Andreasyan G, Sargsyan S, Nersisyan L, Arakelyan A. Molecular Analysis of SARS-CoV-2 Lineages in Armenia. Viruses, 2022
Nersisyan S, Gorbonos A, Makhonin A, Zhiyanov A, Shkurnikov M, Tonevitsky A. isomiRTar: a comprehensive portal of pan-cancer 50-isomiR targeting. PeerJ, 2022
Loeffler-Wirth H, Rade M, Arakelyan A, Kreuz M, Loeffler M, Koehl U, Reiche K, Binder H. Transcriptional states of CAR-T infusion relate to neurotoxicity – lessons from high-resolution single-cell SOM expression portraying. Frontiers in Immunology, 2022
Binder H, Schmidt M, Hopp L, Davitavyan S, Arakelyan A, Loeffler-Wirth H. Integrated Multi-Omics Maps of Lower-Grade Gliomas. Cancers, 2022
Nersisyan S, Zhiyanov A, Zakharova M, Ishina I, Kurbatskaia I, Mamedov A, et al. Alterations in SARS-CoV-2 Omicron and Delta peptides presentation by HLA molecules. PeerJ, 2022
Nikoghosyan M, Loeffler-Wirth H, Davidavyan S, Binder H, Arakelyan A. Projection of High-Dimensional Genome-Wide Expression on SOM Transcriptome Landscapes. BioMedInformatics, 2022
Loeffler-Wirth H, Hopp L, Schmidt M, Zakharyan R, Arakelyan A, Binder H. The Transcriptome and Methylome of the Developing and Aging Brain and Their Relations to Gliomas and Psychological Disorders. Cells, 2022
Goukassian D, Arakelyan A, Brojakowska A, Bisserier M, Hakobyan S, Hadri L, et al. Space flight associated changes in astronauts’ plasma-derived small extracellular vesicle microRNA: Biomarker identification. Clinical and Translational Medicine, 2022

2021

Schmidt M, Arshad M, Bernhart SH, Hakobyan S, Arakelyan A, Loeffler-Wirth H, Binder H. The Evolving Faces of the SARS-CoV-2 Genome. Viruses, 2021
Willscher E, Hopp L, Kreuz M, Schmidt M, Hakobyan S, Arakelyan A... Binder H. High-Resolution Cartography of the Transcriptome and Methylome Landscapes of Diffuse Gliomas. Cancers, 2021
Al-Sanea MM, Chilingaryan G, Abelyan N, Sargsyan A, Hovhannisyan S, Gasparyan H, et al. Identification of Novel Potential VEGFR-2 Inhibitors Using a Combination of Computational Methods for Drug Discovery. Life, 2021